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Record W2369326609

Reconstruction of genetic regulatory network from omics data

2010· article· en· W2369326609 on OpenAlexaff
Yanming Zhu

Bibliographic record

VenueChina Journal of Bioinformatics · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsScience North
Fundersnot available
KeywordsGene regulatory networkBayesian networkComputational biologyComputer scienceBiomedicineBiological networkArtificial lifeSystems biologyBiologyGeneTheoretical computer scienceArtificial intelligenceData scienceGenetics
DOInot available

Abstract

fetched live from OpenAlex

The regulatory networks of life system arise from complex interactions between genes,or other molecules,and all life they phenomenon come from the genetic networks,for example,metabolic networks,transcriptional regulatory networks,signaling networks,protein-protein interaction,and so on.So the network will be the complexity genius and most important character of life,and for emerging the law of life science,reconstructing genetic networks will be fascinating and getting hot.This paper have introduced some models for reconstructing genetic regulatory networks from transcription data,such as boolean network,liner model,differential equations and bayesian networks,and discussed the models' developments and applications.Meanwhile,we also have simple discussed the advances in reconstructing networks from genome sequences,protein-protein interactions information and biomedicine literature,for unfolding the complex mechanisms of life at system level.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.392
Threshold uncertainty score0.526

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.218
Teacher spread0.210 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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