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Record W2373073631

Health Effect Data Needs in Foreign New Chemicals Management

2009· article· en· W2373073631 on OpenAlex
Zhengtao Liu

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueThe Research of Environmental Sciences · 2009
Typearticle
Languageen
FieldChemical Engineering
TopicChemical Safety and Risk Management
Canadian institutionsnot available
Fundersnot available
KeywordsHuman healthBusinessHazardous wasteRisk assessmentTest (biology)Occupational safety and healthEnvironmental healthEnvironmental planningRisk analysis (engineering)EngineeringMedicineComputer scienceEnvironmental scienceWaste managementComputer securityBiology
DOInot available

Abstract

fetched live from OpenAlex

The relevant acts,regulations and executive department and evaluation frameworks for new chemicals management in the EU,United States,Japan,Canada and Australia were introduced and summarized in this paper.The health effect data needs and their test methods for chemicals declaration were expounded in detail.The test data of ocular/dermal irritation/corrosion,skin sensitization,acute toxicity and genetic/chromosomal toxicity are elemental requirements in the EU,Canada and Australia.Japan pays much attention on new chemicals test data of persistence,bioaccumulation,and human/environmental toxicity rather than acute toxicity.In the United States,the predicted health effect data by SARs/QSARs are essential;if it is difficult to make a conclusion whether a chemical poses potential risk of injury to human health/environment,testing data is required.On the contrary,QSARs method is accepted with discretion in Australia.Finally,the management regulation of new chemicals in China was presented briefly.In view of other countries' experience,some complementary proposals about the registered new chemicals data base,QSARs,PET assessment and GLP laboratory on the health effect data needs and their management were presented.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.728
Threshold uncertainty score0.312

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.073
GPT teacher head0.367
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it