The Nicotinic Acetylcholine Receptors and Its Subunits:From Structure to Function
Bibliographic record
Abstract
The nicotinic acetylcholine receptors are legend-gated ion channels. Each receptor is composed of 5 subunits, and each subunit has 4 α-helix transmembrane domains. The channel pore is shaped by an inner ring of 5 α-helices of M2, which curve radially to create a tapering path in the middle of membrane, and an outer ring of 15 α-helices which coil around each other and shield the inner ring from the lipid. So far 17 subunits of the receptors have been determined, which belong to a big gene family with a same origin and are expressed in the central nervous system, peripheral nervous system and muscle tissue. There are so many subunits and specific expression in different tissues, which result in their many physiological and pharmacological features and functions. Recently genetically manipulated mice, such as gene knock-out mice, have greatly increased our understanding of the sub- unit composition and physiological properties of the receptors in vivo. In this article, we review the related researching progress.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".