Determination of the dissolution of benazepril hydrochloride and hydrochlorothiazide tablets by HPLC
Bibliographic record
Abstract
The rotating basket method was used to determine the dissolution of benazepril and hydrochlorothiazide tablets with 0. 1mol / L hydrochloric acid as dissolution medium at the rotating speed of 100 r / min. And the dissolved samples were determined by HPLC every 30min,using C18( 250 ×4. 6mm,5μm) column and tetrahydrofuran-water-acetic acid glacial( 25∶ 75∶ 0. 4) as mobile phase. The flow rate was set at 1. 0 mL / min. The column temperature was set at 25℃. The calibration curves for hydrochlorothiazide and benazepril were good linear in the range of 0. 999 2 ~ 14. 99μg / mL( r = 0. 999 7) and 0. 798 4 ~ 9. 581 μg / mL( r = 0. 999 6),the average recoveries were 99. 9% and 100. 2%,respectively. The dissolutions of benazepril and hydrochlorothiazide were determined simultaneously. This method was simple and accurate. The results were reliable so that it could be used to determine the dissolution of benazepril hydrochloride and hydrochlorothiazide tablets for quality control of pharmaceutical preparations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".