Tissue Distribution and Excretion of Radioactivity in Mice After Intragastric Administration of ~3H-β,β-dimethylacrylshikonin
Bibliographic record
Abstract
Tissue distribution and excretion of radioactivity in mice after intragastric admin- istration of ~3H-β,β-dimethylacrylshikonin were investigated.Tissues and feces were com- busted by sample Oxidizer,the subsequent radioactivity measurements were carried out af- ter addition of scintillator to the combusted samples and urine.The results showed that the radioactivity in gastrointestinal system was higher than that in the liver,lung,kidney and heart,while that in skeletal muscle,spinal cord,brain was lower.After single intragastric administration(chemical dose 84.0 mg/kg,radioactive dose 22.3 MBq/kg)ofβ,β-dimethy- lacrylshikonin to mice,the cumulative radioactivity excretion rate of urine and feces were (8.43±0.26)% and(72.87±9.92)% respectively within 336 h ,the total excretion rate was(81.30±9.79)%.The samples of plasma,feces and urine were also analyzed by HPLC.The rsult is that parent drug mainly existed in feces,not in plasma or urine.This study showed that ~3 H-β,β-dimethylacrylshikonin was distributed widely in mice,and excre- ted mostly through fecal route and secondarily via urine.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".