Clinical significance of soluble CD40 ligand in patients with subcortical ischemic cognitive impairment
Bibliographic record
Abstract
Objective To evaluate the level of soluble CD40 ligand(sCD40L) in the serum of patients with subcortical ischemic vascular disease(SIVD)and the correlation with cognition and white matter lesions(WML).Methods 19 patients with VD,20 patients with VCIND and 15 gender and age matched normal controls(NC) were recruited.All subjects were underwent neuropsychological assessment and conventional MRI.The serum level of sCD40L was detected by enzyme linked immunosorbent assay(ELISA) in all subjects.In addition,the relationship was described among sCD40L,WML and cognitive impairment in patients with SIVD.Results(1) A statistically increase of sCD40L serum level of SIVD patients versus healthy controls was detected(P0.05).No significant difference between VD and VCIND groups was observed(P0.05).(2) There was no statistically correlation between the serum level of sCD40L and MMSE,MoCA,WML scores(P0.05).Conclusions(1) Increased serum level of sCD40L in patients with SIVD might indicate that inflammatory processes may be activated in SIVD.(2) Enhanced serum level of sCD40L could not imply the association with the severity of cognitive impairment and WML in SIVD patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".