Transplantation of human islets in 8 diabetic patients with Edmonton immanosuppressive protocol
Bibliographic record
Abstract
Objective To investigate the clinical effect of adult human islet transplantation in the treatment of patients with type 1 diabetes mellitus.Methods Eight patients with type 1 diabetes were transplanted with adult human islets from 1 or 2 cadaveric donors.The islets were digested,se- parated and cultured overnight,then transfused into the hepatic artery of each recipient through artery intubatton.The amount of islets for each recipient was(8415±757)IEQ/kg.Three recipients re- ceived 1 donor pancreas,and other 5 recipients received 2 donor pancreases(by 2 times of transplanta- tions).In the 8 recipients,ABO blood type between the recipients and the donors were corresponded to each other except 1 recipient.The 8 recipients did not accept pretransplant human leukocyte antigen (HLA)crossmatch.The Edmonton's immunosuppressive protocol was used after the transplanta- tions.The dosage of insulin injection,the level of serum C-peptide and blood glucose after operation were examined.Results The median duration of follow-up after initial transplantation was 7.7 months.Two patients were insulin-independent after 2 transplantation procedures.Five recipients have achieved 47%-90% reduction of exogenous insulin dosage.In one recipient after two islets transplantations,the dosage reduction of insulin injection just was 21%.The levels of blood glucose in 8 recipients were decreased markedly from(10.6±3.9)mmol/L to(6.6±1.3)mmol/L(P0.05).HbAlc levels were reduced from(11.9±1.6)% to (5.9±1.2)%(P0.01).Fasting and glucose tolerance-stimulated serum C-peptide was increased significantly from(0.054±0.076)nmol/ L and(0.075±0.045)nmol/L to(0.620±0.080)nmol/L and(1.580+0.770)nmol/L(P0.01). Complication related to immunosuppressants was hypoleukemia(6 cases),which was cured after re- duction and withdrawal of immunosuppressants.No complications such as massive haemorrhage,por- tal vein embolism,or portal hypertension happened.Conclusion It is effective for islet transplantation through the hepatic artery in the treatment of the patients with type 1 diabetes mellitus.The Edmon- ton's immunosuppressive protocol is safe and effective.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".