Evaluation of the hot and cold characteristics of seven antiarrhythmic drugs by cytological method
Why this work is in the frame
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Bibliographic record
Abstract
Objective: To evaluate the hot and cold characteristics of 7 antiarrhythmic drugs.Methods: MTT assay was used to investigate the effect of 7 antiarrhythmic drugs on the growth and proliferation of SMMC7721 cells and MFC-7 cells in vitro.Morphological changes were observed with inverted microscope.Results: Diltiazem hydrochloride,verapamil hydrochloride,amiodarone hydrochloride,propafenone hydrochloride showed cold or cool characteristics,and metoprolol tartrate,bisoprolol fumarate,carvedilol showed hot or warm characteristics.Morphological observation demonstrated that cells treated with diltiazem hydrochloride,verapamil hydrochloride,amiodarone hydrochloride,propafenone hydrochloride showed lower cell density and rounder pyknosis.The cells treated with metoprolol tartrate,bisoprolol fumarate,carvedilol showed higher cell density,tighter cell structure and more vigorous growth.Conclusion: The cytological method could be used to evaluate the hot and cold characteristics of western drugs,which may provide a simple and practical evaluation method for Chinese medicalization of western drugs.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it