New prospect on research and development of Chinese Materia Medica and phytomedicines in global
Bibliographic record
Abstract
With the global changes of the disease spectrum and the needs of health,it is now the knotty problem and huge challenge for the pharmaceutical industries to ensure the continuous RD and the sustainability of market for the innovative drugs worldwide.In recent years,US,EP,and Canada issued the new regulations on the phytomedicine,which not only means they will have the equal status compared to the non-botanical drugs,but also more flexibility on the regulations of the approval and launch on the market.In this paper,the different regulations of phytomedicine and botanical products in the US,EP and Canada are introduced,the process of the series of RD of Dantonic(Fufang Danshen Dripping Pill,the 1st CMM compound drug with the FDA IND approval) and its global Phase II clinical trial since 1997 reviewed,the experiences on the regulatory conversation with FDA summarized,and the new prospect on the future global RD of chinese materia medica put forward.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".