Synthesis of Isoalloxazine Modified C_(60)-polypropylene Acid and Its Interaction with DNA
Bibliographic record
Abstract
Poly(acrylic acid) conjugated fullerene(C60-PAA) is synthesized by free-radical polymerization.C60-PAA is covalently linked with riboflavin analogue 6,7-Dimethyl-9-(2′-hydroxyethyl)-isoalloxazine through esterification reaction,affording C60-PAA-DHIX.The products are characterized by Fourier transform infrared spectroscopy(FT-IR),proton nuclear magnetic resonance(1HNMR),UV-visible absorption spectroscopy(UV-Vis),and fluorescence spectroscopy.Cyclic voltammetry results show that the first reduction potential of fullerene moiety is higher than that of DHIX moiety in C60-PAA-DHIX.ESR results indicate that multi-step photoinduced electron-transfer processes may occur between C60-PAA-DHIX and N,N-dimethyl aniline under irradiation.One-electron transfer from N,N-dimethyl aniline to excited-state DHIX induces the generation of DHIX-· radical,followed by electron transfer from the DHIX-· radical to C60,forming the corresponding anion radical of C60(C60-·).The results obtained from DNA melting experiments,UV-Vis absorption and fluorescence spectra suggest that C60-PAA-DHIX could interact with CT DNA through groove binding mechanism.However,C60-PAA can only weakly interact with DNA.C60-PAA-DHIX exhibited stronger DNA photodamage ability on plasma DNA than C60-PAA under anaerobic condition.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".