Role of oxidative stress and sleep structure on cognitive dyfunction in patients with obstructive sleep apnea-hypopnea syndrome
Bibliographic record
Abstract
Objective: To investigate the possible biochemical mechanism of cognitive dyfuntion in patients with obstructive sleep apnea-hypopnea-hypopnea syndrome( OSAHS). Methods: Polysomnography was administered to twenty-eight patients with OSAHS and sixteen education and BMI-matched controls,all the cases were measured serum superoxide dismutase( SOD) and malondialdehyde( MDA) level by spectrophotometry and underwent the Montreal Cognitive Assessment. Results: The scores of MoCA and its subitems including calculation,language and delay recall in the patients with OSAHS were significantly lower than those in the controls( P 0. 01). The serum MDA level in patients was significantly higher than that in the controls( P 0. 01). The serum SOD level in patients was significantly lower than that in the controls( P 0. 01). The level of MDA and SOD was significantly correlated with the percentage of time during sleep spent with an oxygen saturation below 80% and the scores of MoCA and its subitems including calculation,language and delay recall( P 0. 05). Conclusion: Oxidative stress may play an important role in cognitive impairment in patients with OSAHS.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".