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Record W2387775612

Protein Crystallization Experiments Aboard Shenzhou-8 Spacecraft

2012· article· en· W2387775612 on OpenAlexaboutno aff
Ma Jianhua

Bibliographic record

VenueKeji daobao · 2012
Typearticle
Languageen
FieldMedicine
TopicSpaceflight effects on biology
Canadian institutionsnot available
Fundersnot available
KeywordsProtein crystallizationCrystallizationDiffractionCrystallographyX-ray crystallographyCrystal (programming language)Resolution (logic)ChemistryMaterials sciencePhysicsOpticsComputer science
DOInot available

Abstract

fetched live from OpenAlex

The crystallization experiments of 14 proteins were carried out,the experiment was lasted 16.5 days by using German Biobox facility and self-developed growth chambers aboard Shenzhou-8 spacecraft.The counterpart experiment was performed on the ground laboratory according to the same timing sequence.The results show that 12 of 14 proteins precipitate crystals in space experiment,11 of 14 proteins precipitate crystals on ground experiment.Eight space-grown crystals of four proteins are applied to synchrotron radiation,and eight set diffraction data are obtained.In the meantime,five earth-grown crystals of three proteins are applied to synchrotron radiation,and five set diffraction data are obtained,among them,one set is incomplete.The highest preliminary diffraction resolutions of space-and earth-grown lysozyme crystals are 1.16 and 1.23,respectively.However,is the highest resolutions are 1.75 and 1.49,respectively for the crystals of diadenosine tetraphosphate from dysentery bacillus;nevertheless one space-grown crystal has different crystallographic symmetry from other crystals.The highest diffraction resolution for the space-grown crystal of the chlamydial protease-like activating factor diffracted is 2.31,the ground one fails to diffraction.The highest diffraction resolution for the space-grown crystal of 17β-hydroxysteroid dehydrogenase type 7 complex from Canada is 2.30,the ground one is not good enough for collecting a complete diffraction data set.The growth chambers used in space experiment adopt a new structure for the first time in the world of which the protein solution container is made of glass capillary and immersed in the precipitation solution.The new growth chamber is portable,works without power supply,and is able to eliminate Marangoni convection in the vapor diffusion chamber.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.351
Threshold uncertainty score0.822

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.309
Teacher spread0.285 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2012
Admission routes1
Has abstractyes

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