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Record W2387819460

EXPRESSION AND CHANGE OF GDNF IN THE NEURONS OF L_(4-6) DRG AFTER SCIATIC NERVE INJURY IN RAT

2001· article· en· W2387819460 on OpenAlexaff
Yu Dong

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldMedicine
TopicHealthcare and Venom Research
Canadian institutionsCAE (Canada)
Fundersnot available
KeywordsGlial cell line-derived neurotrophic factorSciatic nerveSciatic nerve injuryImmunohistochemistryMedicineNerve injuryAnatomyNeurosciencePathologyInternal medicineBiologyAnesthesiaNeurotrophic factorsReceptor
DOInot available

Abstract

fetched live from OpenAlex

Objective In order to investigate the localization of GDNF in the L\-\{4\|6\} DRG neurons of adult rat after crushing the right sciatic nerve. Methods The anti\|GDNF ABC immunohistochemical staining technique and image analysis method were used on the L\-\{4\|6\} DRG neurons of adult rat 1d,3d,5d,7d,10d,14d,28d and 56d after crushing the right sciatic nerve respectively. Results The positive GDNF immunoreactivity was present in the neurons of L\-\{4\|6\} DRG 1d,3d,5d,7d,10d,14d,28d and 56d after crushing the right sciatic nerve.Image analysis demonstrated that the optical densities of the right DRG neurons during 1 to 7 days post injury were higher than that in the left. Conclusions The present results suggested that GDNF existed in the sensory neurons of L\-\{4\|6\} DRG of adult rat.The expression of GDNF by the right DRG neurons was increased in the first week after crushing the right sciatic nerve.\;

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.037
Threshold uncertainty score0.228

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.104
GPT teacher head0.408
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2001
Admission routes1
Has abstractyes

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