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Record W2390703118

Effect of Benazepril on cardiac failure model and its mechanism

2004· article· en· W2390703118 on OpenAlexaff
JI Hong-zan

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldChemistry
TopicAnalytical Methods in Pharmaceuticals
Canadian institutionsCAE (Canada)
Fundersnot available
KeywordsBenazeprilAldosteroneInternal medicineHeart failureRenin–angiotensin systemMedicineEndocrinologyRadioimmunoassayAngiotensin IICardiologyBlood pressure
DOInot available

Abstract

fetched live from OpenAlex

AIM: To study the effect of Benazepril on plasma angi ot ensin Ⅱ(AngⅡ) and aldosterone(ALDO) levels in the rat heart failure model. METHODS: The cardiac failure animal model in rats were made by coarc tating abdomial aorta to get pressure load. The rats aged 8 months were divid ed into three groups: the heart failure group(n=34), the treatment grou p(n=34)and the control group(n=16). Plasma angiotensin Ⅱ and aldost erone were measured by radioimmunoassay(RIA). RESULTS: The angiot ensin Ⅱ and aldosterone levels in the heart failure group were markedly higher than those in the others proups(P0.01). It was shown that angiotensin Ⅱ a nd aldosterone levels in the rats were correlated with cardiac failure in this research. The angiotensin Ⅱ and aldosterone levels of the treatment group decr eased was obvious after benazepril therapy (P0.01). CONCLUSION: Angiotensin Ⅱ and aldosterone played an important role in the pathogenes is of heart failure. Benazepril(ACEI) had a positive effect on the treatment and prognosis of cardiac insufficiency.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.308
Threshold uncertainty score0.463

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.357
Teacher spread0.329 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2004
Admission routes1
Has abstractyes

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