Effects of Resveratrol on Expression of PPARγ and Related Inflammatory Factors in Rabbits with Atherosclerosis
Bibliographic record
Abstract
Aim To explore the effect and its possible mechanism of resveratrol on atherosclerosis.Methods 42 Mature male New Zealand white rabbits were randomly divided into three groups: rabbits in blank group treated with normal diet,rabbits in model group treated with high fat diet,rabbits in resveratrol group treated with high fat diet and resveratrol at the dosage 16 mg/(kg·d).All rabbits were fed according to experiment design for 12 weeks.The aortas were harvested for histopathological examination.Apoptosis was detected by TUNEL,the mRNA transcription of PPARγ,Fas,FasL and Caspase-3 were examined by RT-PCR and MCP-1,MMP-9 and TIMP-1 were examined by ELISA. Results Atherosclerosis model was successfully established.Atherosclerotic lesions in the resveratrol group were significantly reduced.Resveratrol inhibited apoptosis of cells in the plaque.In the resveratrol group PPARγ transcription increased,Fas,FasL and Caspase-3 mRNA transcription was significantly decreased.The protein expression levels of MCP-1 and MMP-9 were significantly reduced,TIMP-1 protein expression was increased.Conclusions Resveratrol has anti-atherosclerotic role,which may be as a natural agonist through upregulating the PPARγ gene transcription within the plaque,reducing Fas,FasL and Caspase-3 transcription,and reducing the expression of MCP-1,MMP-9 while promoting TIMP-1 expression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".