Studies on immunoprotection against Schistosoma japonicum induced by phage display peptides mimicking the epitopes of 22.6kDa antigen of Schistosoma japonicum
Bibliographic record
Abstract
Objective To obtain the short peptides mimicking antigenic epitopes of 22.6?kDa antigen of Schistosoma japonicum(Sj) from phage display library,and explore their cross protective immunity against Sj in mice.Methods Purified polyclone IgG antibody against the Sj 22.6?kDa were used to immunoscreen a 12 mer phage display library for the epitopes of Sj 22.6?kDa.Five rounds of biopanning were carried out and 24 clones from the fifth round biopanning were random selected,identified by Western blot and sequenced.The mice were immunized with the obtained 4 positive clones.Results Four different epitopes of Sj 22.6?kDa were obstained.Conclusion Antigenic epitopes of Sj 22.6?kDa can be prepared by immunoscreening phage display library,a significant protective immunity against Sj can be induced by these epitopes in mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".