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Record W2394450086

Disequilibrium transmission of Ser9Gly polymorphism of Dopamine D_3 receptor gene in 151 schizophrenia families

2000· article· en· W2394450086 on OpenAlexaff
Rulun Zhou

Bibliographic record

VenueThe Journal of Beijing Medical University · 2000
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
Topic14-3-3 protein interactions
Canadian institutionsCAE (Canada)
Fundersnot available
KeywordsTransmission disequilibrium testDisequilibriumGenotypeAlleleSchizophrenia (object-oriented programming)Polymorphism (computer science)GeneticsLinkage disequilibriumBiologyPsychologyGeneInternal medicinePsychiatryHaplotypeMedicine
DOInot available

Abstract

fetched live from OpenAlex

The distributions of alleles or genotypes of DRD3 Ser9Gly polymorphism are not significantly different between the groups of parents, unaffected-siblings and affected-siblings, and between the sub-types of schizophrenia. The transmission disequilibrium test (TDT) shows the transmission disequilibrium in affected-siblings (X~(2)=7.76, P=0.005 3, OR=1.70, 95%IC:1.15-2.52). The correlation analysis was taken between genotypes and clinical status. The results show that schizophrenia siblings with Ser9 allele are apt to have negative symptoms. The results show that there may exit association between DRD3 and schizophrenia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.047
Threshold uncertainty score0.470

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.206
Teacher spread0.202 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2000
Admission routes1
Has abstractyes

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