Cruciferin coating improves the stability of chitosan nanoparticles at low pH
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Encapsulation is an emerging technique to improve the solubility, permeability and bioavailability of bioactive compounds. Cruciferin, a major canola protein, has the potential to protect chitosan-based delivery systems under the gastric conditions due to its resistance to gastric digestion. Positively charged spherical nanoparticles with an average size of 165 nm were prepared. Two water-soluble and -insoluble model compounds (brilliant blue and β-carotene) were encapsulated. The characteristic studies of the particles showed that the chitosan-based core was coated by a cruciferin layer mainly through hydrogen bonding based on FTIR, DSC, surface hydrophobicity, dissociating and intrinsic fluorescence studies. The particles did not show toxicity to Caco-2 cells and their cellular uptake was observed using confocal microscopy. Release studies showed that the particles were resistant to simulated gastric and intestinal fluids and released less than 20% of the encapsulated compounds. Our results suggested that the particles are promising carriers for encapsulation of heat, pH and protease-degradable hydrophilic and hydrophobic bioactive compounds.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it