The expression features of serum Cystatin C and homocysteine of Parkinson's disease with mild cognitive dysfunction.
Bibliographic record
Abstract
OBJECTIVE: To discuss the expression features of serum cystatin C, and homocysteine in patients of Parkinson's disease (PD) with mild cognitive impairment. PATIENTS AND METHODS: Patients with PD from the neurology department of the Central Hospital of Xuzhou from august 2012 to august 2014 were enrolled in this study. The Hoehn-Yahr (H&Y) grading rating scale was used to rate the degree of severity of PD, and the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) rating scale was used to rate and group their cognitive impairment, test the level of the serum cystatin C (CysC) and homocysteine (HCY) and their variations after treatment with vitamin B and folic acid. RESULTS: (1) The CysC and HCY in the PD group was higher than that in the normal control (p<0.05); (2) As the H&Y rating upgraded, the CysC and HCY in the PD group gradually increased with the progression of the disease (p<0.05); (3) The level of CysC and HCY in the PD-mild cognitive impairment (MCI) group increased significantly compared with those in the PD group (p<0.05) The correlation analysis showed that there was significant positive correlation between CysC and HCY. (4) After treatment with vitamin B and folic acid, the CysC, and HCY levels were lower than before, but the grades of the repetition measurement scale, MMSE and MoCA had no significant improvement (p>0.05). CONCLUSIONS: A high level of CysC and HCY might be involved in the development of Parkinson disease. Their expression levels were higher in the PD patients with mild cognitive dysfunction and both showed a remarkably positive correlation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".