Anti-androgen treatment of prostatic carcinoma may be a risk factor for development of rheumatoid arthritis.
Bibliographic record
Abstract
There are many rheumatic paraneoplastic syndromes. The association between prostate carcinoma and subsequent development of rheumatoid arthritis (RA) has not been reported. We describe 3 cases of men developing inflammatory arthritis after anti-androgen manipulation for treatment of prostate carcinoma. None had diagnoses supporting other connective tissue disease or crystal arthritis. Only one patient had a weakly positive rheumatoid factor, and another had a positive antinuclear antibody. The cases fulfilled 1987 American College of Rheumatology criteria for RA. The onset of joint symptoms was within weeks to 9 months of starting therapy to suppress testosterone [2 received leuprolide acetate (Lupron) and one cyproterone acetate (Androcur)]. Review of the literature yielded no reports of prostate carcinoma associated with paraneoplastic RA. We review the literature with respect to associations of paraneoplastic RA and prostate carcinoma and discuss published data in the context of the hypothesis of lower testosterone and increased risk of RA.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".