Method for Optimizing Topography-guided Ablation of Highly Aberrated Eyes With the ALLEGRETTO WAVE Excimer Laser
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
PURPOSE: To evaluate the clinical outcomes of custom topographic neutralizing technique in treating highly aberrated eyes using the WaveLight ALLEGRETTO WAVE Excimer Laser. METHODS: A retrospective consecutive case series of 67 eyes with decentered ablations and 48 eyes with symptomatic small optical zones after previous LASIK underwent topography-guided retreatment with the ALLEGRETTO WAVE. Sixteen keratoconus eyes underwent topographic neutralizing technique photorefractive keratectomy (PRK). The study assessed preoperative and 6-month and 1-year postoperative results regarding best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), topography, and predictability. RESULTS: Sixty-seven eyes with previously decentered optical zones had an improvement of centration from 0.92 mm preoperatively to 0.30 mm postoperatively relative to pupil center (P<.01). Twenty-nine percent of these eyes gained 1 or more lines of BSCVA, whereas 71% had no change in BSCVA. Forty-eight eyes with previously small optical zones had an increase of the central monodioptric optical zone from 3.9 mm to 5.6 mm (P<.01). Nineteen percent of eyes had an improvement of at least 1 line, whereas 75% had no change in BSCVA and 6% lost 1 line. Sixteen keratoconus eyes had custom topographic neutralizing technique PRK as an alternative to penetrating keratoplasty. All eyes had improvement of astigmatism up to 5.00 diopters (D), with a mean change of 1.68+/-1.62 D. Best spectacle-corrected visual acuity was unchanged in 8 (50%) eyes, with 4 (25%) eyes gaining 1 line, 2 (12%) eyes gaining 2 lines, and 2 (12%) eyes losing 1 line of BSCVA at 6 months. CONCLUSIONS: Management of some highly aberrated eyes is now possible with topography-guided ablation using the WaveLight ALLEGRETTO platform and custom topographic neutralizing technique. Safety was acceptable for small optical zone and decentered ablation retreatments. The topography-guided ablation could be an alternative treatment for keratoconus patients if keratoplasty is otherwise indicated. The algorithms for custom topographic neutralizing technique need further refinement.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it