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Record W2399784887 · doi:10.1159/000459517

The Ultrastructural Localization of AlkalinePhosphatase Isoenzymes in Some Normaland Malignant Cells

2017· article· en· W2399784887 on OpenAlexaff
Viliam Lustig, John A. Kellen

Bibliographic record

VenueEnzymologia biologica et clinica · 2017
Typearticle
Languageen
FieldMedicine
TopicAlkaline Phosphatase Research Studies
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsThermolabileIsozymeAlkaline phosphataseThermostabilityBiochemistryEnzymeUltracentrifugePhosphataseChemistryUltrastructureMicrosomeBiologyMolecular biologyAnatomy

Abstract

fetched live from OpenAlex

(1) Alkaline phosphatases were present in all subcellular fractions obtained by ultracentrifugation of all the tissues examined. (2) The highest specific activities (mU/mg protein) were found in the microsomal fractions, the lowest in the supernatant, with the exception of the mammary tumour examined. (3) A different thermostability of the enzymes in the various fractions pointed to the presence of isoenzymes; a biphasic curve gave evidence of the simultaneous presence of at least two isoenzymes in some particulate structures. (4) There was no specific thermolabile pattern of alkaline phosphatases in the malignant tissues examined, assuming the method used is valid for establishing such differences.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.007
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.102
Threshold uncertainty score0.793

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.043
GPT teacher head0.382
Teacher spread0.339 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2017
Admission routes1
Has abstractyes

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