Pathophysiology of Blood–Brain Barrier Breakdown
Why this work is in the frame
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Bibliographic record
Abstract
The innovative experiments of Paul Ehrlich (1) more than a century ago were the first to demonstrate that the permeability properties of cerebral vessels were different from those of non-neural vessels. He injected the aniline dye coerulean-S intravenously into rats and found that all body organs turned blue but the brain did not. These findings were later confirmed by Bouffard (2) and Goldmann (3) using intravenously injected trypan blue. These early studies led to the recognition of a barrier between blood and brain, which was not passable by trypan blue and which also led to the hypothesis at that time that the barrier was at the endothelium of intracerebral vessels (4). Although the term “blood-brain barrier” (BBB) was introduced to describe the absolute restriction of penetration of certain molecules into the brain, it now includes a variety of mechanisms, which maintain cerebral homeostasis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it