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Adaptive Plasticity in the Spinal Control of Left‐right Coordination During Locomotion

2015· article· en· W2403877344 on OpenAlexaff
Alain Frigon, Charline Dambreville, Yann Thibaudier, Marie‐France Hurteau, Victoria Kuczynski, Emily Rhodes

Bibliographic record

VenueThe FASEB Journal · 2015
Typearticle
Languageen
FieldVeterinary
TopicVeterinary Orthopedics and Neurology
Canadian institutionsUniversité de Sherbrooke
Fundersnot available
KeywordsDenervationCATSAnatomyMedicineAnkleTreadmillHindlimbNeurectomyPhysical medicine and rehabilitationInternal medicine

Abstract

fetched live from OpenAlex

Hindlimb (HL) locomotion recovers in chronic spinal‐transected cats following ankle extensors neurectomy (Bouyer et al. 2001), indicating compensatory spinal mechanisms. However, such recovery has only been tested during single‐belt treadmill locomotion at moderate speeds (0.35 m/s to 0.5 m/s). Here, HL locomotion was assessed at several speeds and left‐right speed differences during tied‐belt (equal left‐right speeds) and split‐belt (unequal left‐right speeds) locomotion, respectively, in 4 chronic spinal‐transected cats implanted with chronic electrodes for EMG. Spinal transection was made at the last thoracic segments and cats were trained to recover HL locomotion. A unilateral denervation of the lateral gastrocnemius and soleus was made after stable HL locomotion had recovered, at least 1 month post‐transection. Denervation produced variable results between cats. In the most affected cat, the denervated HL made abnormal contacts with the paw dorsum and left and right HLs were not coordinated 1‐2 days post‐denervation, producing an unstable locomotion. Although the pattern gradually stabilized over several weeks, plantigrade placement of the denervated HL was facilitated only if the non‐denervated HL stepped faster during split‐belt locomotion. In the opposite split‐belt condition, the pattern remained unstable. In the least affected cat, although no abnormal paw placements were observed 1 day post‐denervation, HL locomotion was considerably more stable with the denervated HL stepping faster during split‐belt locomotion. Preliminary results suggest that ankle extensors are important for the spinal control of left‐right coordination and that adaptation can be shaped by split‐belt locomotion.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.066
GPT teacher head0.300
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2015
Admission routes1
Has abstractyes

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