Effects of glutathione supplementation during peritoneal dialysis.
Bibliographic record
Abstract
We examined the effect of L-2-oxothiazolidine-4-carboxylate (OTZ) on peritoneal morphology and function of mesothelial cells in rats during peritoneal dialysis (PD). We implanted intraperitoneal catheters into 14 rats and injected the rats twice daily for 4 weeks with standard PD fluid (group C, control; n = 7) or PD fluid supplemented with OTZ 1 mmol/L (group OTZ; n = 7). At the beginning and the end of the study, we collected samples of 4-hour dwell effluents from every rat under sterile conditions. We used those samples to test, in ex vivo conditions, the effect on primary cultures of rat peritoneal mesothelial cells with regard to synthesis of total protein and collagen in mesothelium. After 4 weeks, the rats were humanely killed, and glutathione peroxidase activity in erythrocytes was measured. Morphologic analysis of the peritoneal membrane was also performed. As compared with group OTZ, group C showed intraperitoneal adhesions that were more severe, a higher density of mesothelial cells, a higher density of peritoneal vessels, similar peritoneal thickness, lower activity of glutathione peroxidase, and greater ability of their dialysate effluent to induce synthesis of total proteins and collagen in cultured mesothelial cells. Relationships between various parameters were analyzed. We conclude that OTZ preserves peritoneal morphology and the function of mesothelial cells during PD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".