Function of Thyroid Hormone Receptors During Amphibian Development
Bibliographic record
Abstract
Thyroid hormone (T3) plays important roles during vertebrate development (). In humans, T3 is detected in the embryonic plasma by 6 mo and rises to high levels around birth (). During this postembryonic period, extensive tissue remodeling and organogenesis take place. T3 deficiency during human development leads to developmental defects, such as mental retardation, short stature, and in the most severe form, cretinism (,). Likewise, T3 is also critical for amphibian development. It is the controlling agent of anuran metamorphosis, a process that transforms a tadpole into a tailless frog (,). Blocking synthesis of endogenous T3 leads to the formation of giant tadpoles that cannot metamorphose, while addition of exogenous T3 to premetamorphic tadpoles causes precocious metamorphosis. Importantly, most, if not all, organs are genetically predetermined to undergo specific changes, and these changes are organ autonomous. Thus, T3 appears to act directly on individual metamorphosing organs. Such properties have made anuran metamorphosis one of the best-studied postembryonic developmental process at morphological, cellular, and biochemical levels and paved the way for current molecular investigations of the underlying mechanisms.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".