The slow-acting, symptom modifying effects of colchicine in primary knee osteoarthritis
Bibliographic record
Abstract
Aim: To determine whether the therapeutic use of colchicine along with etodolac (selective cox-2 inhibitor NSAIDs) confer any beneficial effect in the treatment of osteoarthritis of knee joint. Materials and methods: Forty selected subjects were randomized to receive either 0.5 mg of colchicine twice daily or placebo for 26 weeks. Results: Visual analog scale (VAS), Western Ontario and McMaster University Osteoarthritis total scale (WOMAC), and patient global assessment and physician global assessment scores were recorded on day 0, weeks 2, 6, 10, 14, 18, 22 and 26. Improvement rate at the end of 22 week was higher in colchicine group than placebo, as measured by VAS score (46.88 vs.51.11;P=0.033), WOMAC score (18.88 vs.24.56; P=0.019), patient global assessment score(34.69 vs. 38.33; P=0.039) and physician global assessment score (20.00 vs. 26.39; P=0.02). Conclusion: Subjects receiving colchicine plus etodolac exhibited significantly better symptom control at the end of 22 weeks than the placebo group.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".