Small-Angle X-Ray Scattering Studies of Membrane Transporter Peripheral Components and Soluble Domains
Bibliographic record
Abstract
Structural data are critical for an understanding of how membrane transport systems function; unfortunately, high-resolution crystal structures for these systems are rare, primarily because of difficulties in crystallization. One alternative approach to the structure problem is to dissect the system into individual components and domains; that is, the integral membrane components of transporters are often multisubunit complexes that interact with soluble, peripheral subunits, or they may contain domains that can be expressed as soluble proteins. Structural information for individual domains and soluble components of the system will help to illuminate the mechanism, and this information can be integrated into models for the structure of the complete system. Small-angle X-ray scattering (SAXS) is a method that can be used to investigate the low-resolution structure and conformational changes of soluble proteins, without the requirement for crystals (for examples, see refs. 1–9).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".