Oral mycophenolate led to more complete remissions than intravenous cyclophosphamide for active lupus nephritis
Bibliographic record
Abstract
TherapeuticsMay 1, 2006Oral mycophenolate led to more complete remissions than intravenous cyclophosphamide for active lupus nephritisMike Walsh, MD, Braden Manns, MDMike Walsh, MDUniversity of Calgary, Calgary, Alberta, Canada (M.W., B.M.)Search for more papers by this author, Braden Manns, MDUniversity of Calgary, Calgary, Alberta, Canada (M.W., B.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2006-144-3-074 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationGinzler EM, Dooley MA, Aranow C, et al. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med. 2005;353:2219-28. https://pubmed.ncbi.nlm.nih.gov/16306519Clinical Impact RatingsAllerg & Immunol: Nephrology: References1 Chan TM, Li FK, Tang CS, et al. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N Engl J Med. 2000;343:1156-62. [PMID: 11036121] Google Scholar2 Hu W, Liu Z, Chen H, Tang Z, et al. Mycophenolate mofetil vs cyclophosphamide therapy for patients with diffuse proliferative lupus nephritis. Chin Med J (Engl). 2002;115:705-9. [PMID: 12133539] Google Scholar3 Ong LM, Hooi LS, Lim TO, et al. Randomized controlled trial of pulse intravenous cyclophosphamide versus mycophenolate mofetil in the induction therapy of proliferative lupus nephritis. Nephrology (Carlton). 2005;10:504-10. [PMID: 16221103] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Calgary, Calgary, Alberta, Canada (M.W., B.M.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails May 1, 2006Volume 144, Issue 3Page: 74KeywordsAdverse eventsAntibody therapyBiopsyBody weightCreatinineCyclophosphamideDiarrheaGlobal healthGlomerulonephritisHospitalizationsLactationLupus erythematosusLupus nephritisMonoclonal antibodiesNephrologyProteinuriaRed blood cellsRheumatologySerum proteinsUrine ePublished: 9 March 2020 Issue Published: May 1, 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".