Bibliographic record
Abstract
The complex O -linked oligosaccharide chains ( O -glycans) attached to the polypeptide backbone of mucins are assembled by glycosyltransferases. These enzymes act in the Golgi apparatus in a controlled sequence that is determined by their substrate specificities, their localization in Golgi compartments, and their relative catalytic activities ( 1 ). Activities are controlled by many factors, including the membrane environment, metal ions, concentrations of donor and acceptor substrates, cofactors, and, in some cases, posttranslational modifications of enzymes. Cloning of glycosyltransferases has revealed the existence of families of homologous glycosyltransferases with similar actions but encoded by different genes. Thus, many steps in the pathways of O -glycosylation appear to be catalyzed by several related glycosyltransferases that may show slight differences in properties and substrate specificities. The relative expression levels of these enzymes is cell typespecific and appears to be regulated during the growth and differentiation of cells and, during tissue development, and is altered in many disease states ( 2 , 3 ). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.006 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".