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Record W2415461047 · doi:10.1159/000467999

Metabolic Control of Body Temperature in Man

2017· article· en· W2415461047 on OpenAlexaff
Louis Huszka, M. Harvey Little, John W. Lovett Doust

Bibliographic record

VenueInternational Pharmacopsychiatry · 2017
Typearticle
Languageen
FieldMedicine
TopicAdipose Tissue and Metabolism
Canadian institutionsCentre for Addiction and Mental Health
Fundersnot available
KeywordsSerotoninTryptophanRectal temperatureEndocrinologyInternal medicineHypothalamusDrugMedicineBiologyPharmacologyBiochemistry

Abstract

fetched live from OpenAlex

The Feldberg and Myers (8, 9) hypothesis concerning body temperature regulation asserts that the delicate balance between heat production and heat loss is maintained by the relative activity of serotonin and noradrenalin neurons located in the anterior hypothalamus. This hypothesis is consistent with observations in several species of animals and birds since 1964, but not yet in man. In a therapeutic trial of l-tryptophan in schizophrenia, adequate doses of an MAOI drug and l-tryptophan were administered sequentially to seven human females, with the object of fostering the accumulation of predominantly noradrenalin in the brain by the former and exclusively of serotonin by the latter. Rectal temperatures were measured twice daily. It was found that the MAOI drug alone brought about a fall in body temperature whereas the MAOI drug combined with l-tryptophan caused a rise in the majority of patients.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.343
Teacher spread0.331 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2017
Admission routes1
Has abstractyes

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