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Record W2416312971 · doi:10.1007/978-1-59745-519-0_2

Membrane Lipid Polymorphism

2007· review· en· W2416312971 on OpenAlexaff
Richard M. Epand

Bibliographic record

VenueMethods in molecular biology · 2007
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicLipid Membrane Structure and Behavior
Canadian institutionsMcMaster University
Fundersnot available
KeywordsElasticity of cell membranesMembrane curvatureMembraneLiposomeLipid bilayerBilayerLipid bilayer phase behaviorChemistryPolymorphism (computer science)BiophysicsMicelleLipid bilayer mechanicsMonolayerMembrane fluidityBiological membraneCrystallographyMembrane biophysicsHexagonal crystal systemBiochemistryBiologyOrganic chemistry

Abstract

fetched live from OpenAlex

Bilayers are the most familiar arrangement of phospholipids. However, even as bilayers, phospholipids can arrange themselves in a variety of morphologies from essentially flat structures found in large liposomes or when adhered to a flat solid support, to the curved structures found in small liposomes or as bicontinuous cubic phases. Phospholipids can also arrange themselves as curved monolayers, such as in the hexagonal phase, and they can even form spherical or ellipsoid-shaped micelles. A number of factors will determine the final morphology of a lipid aggregate including the structure of the lipid, the nature of the lipid headgroup and its degree of hydration, and the temperature. In addition to being interesting in its own right, the property of lipid polymorphism can be applied to understand how fundamental intrinsic curvature properties of a membrane alter the physical properties of a membrane bilayer. This, in turn, will affect the functional characteristics of membrane proteins, with several possible mechanisms explaining the coupling of membrane properties with protein function.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0050.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.444
Teacher spread0.395 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations37
Published2007
Admission routes1
Has abstractyes

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