Re: Propionibacterium Acnes Infections after Cranial Neurosurgery. Can J Neurol Sci. 2006;33:292-5
Bibliographic record
Abstract
Unfortunately, the boundaries between GNCSE and encephalopathy may be imprecise and vague.Thus, relevant authors have used the term "allied ictal states" for defining a category of nonconvulsive ictal states in which borderline-NCSE versus TW toxic encephalopathies have been similarly categorized.2 It is not surprising, therefore, that the same clinical condition had been considered as encephalopathy or GNCSE depending on authors' view.Both clinical resolution of the confusional state and electroencephalographic abolition of the epileptiform discharges after the administration of intravenous benzodiazepines is the method of choice to diagnosis GNCSE.However, it is well-known that this approach has numerous limitations on the clinical practice: i/ Both TWs of toxicmetabolic origin and generalized epileptiform discharges may be suppressed with intravenous benzodiazepines; ii/An immediate clinical improvement can be difficult to evaluate in a patient under the hypnotic effects of benzodiazepines (the patients frequently fall deeply asleep); iii/ The absence of a clinical improvement after intravenous benzodiazepines is not always a definite sign of encephalopathy because a delayed normalization of the mental state may occur in GNCSE.The electrographic differentiation between TWs and genuine generalized epileptiform discharges is particularly important in the differential diagnosis between toxic encephalopathy and drug-induced GNCSE.3 Several medications such as ifosfamide, cefepime and baclofen have been related to confusional states.In those cases described as drug-induced GNCSE, the onset of antiepileptic treatment is always accompanied by the withdrawal of the potentially neurotoxic medication.Therefore, it is not possible to establish a unique mechanism responsible for the recovery.In addition, the increased concentration on the central nervous system of the most of these drugs seems to lower the seizure threshold by decreasing brain inhibition mediated by gamma aminobutyric acid.Therefore, a subjacent epileptic mechanism cannot be completely ruled out.Under this scenery, the utilization of simple tools, as those proposed by Boulanger et al 1 is very welcome.A minor criticism is that due to the inclusion of an elevated number of patients with anoxic encephalopathy.Apart from the discussion whether these subjects are suffering from a genuine GNCSE or severe encephalopathy with irreversible cortical injury (some authors consider more probable this last option), 4 it is likely that electroencephalographic patterns associated with hypoxic-anoxic cerebral damage might have some differences respect to those due to toxic, metabolic or septic origin.To summarize, as demonstrated by Boulanger et al, 1 the evaluation of the EEG response to sensory stimulation may be helpful to distinguish TWs and GNCSE.Therefore, this aspect should be carefully analyzed when suspecting encephalopathy or nonconvulsive status epilepticus.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.012 | 0.009 |
| Insufficient payload (model declined to judge) | 0.012 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".