Testosterone Concentrations in Hair of Hypogonadal Men With and Without Testosterone Replacement Therapy
Bibliographic record
Abstract
BACKGROUND: The measurement of testosterone (T) is essential for the diagnosis of male hypogonadism and for monitoring treatment. Samples need to be obtained at specific times in relation to the diurnal rhythm and therapeutic T injections. In this study, we explored the measurement of T in hair as an alternative method to assess gonadal status and long-term T exposure in men. SUBJECTS AND METHODS: Thirty-six male subjects comprising 17 healthy volunteers, 10 untreated hypogonadal men, and nine hypogonadal men receiving T injections were studied. T was measured in serum and in hair. T in hair was measured using a commercially available salivary T enzyme immunoassay kit adapted for this use. RESULTS: The T concentration in the hair of hypogonadal men receiving T injections was significantly higher than that in untreated hypogonadal volunteers, but not eugonadal men. Median T concentrations were 3.66 (range, 0.82-15.00), 0.94 (range, 0.33-3.68), and 1.85 (range, 0.58-3.06) pg/g hair, respectively. CONCLUSIONS: T in hair reflects gonadal status in men and may be useful for monitoring T therapy over several weeks to months in hypogonadal men.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".