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Record W2420035934

Historical statistics support a hypothesis linking tuberculosis and air pollution caused by coal.

2007· article· en· W2420035934 on OpenAlexaboutno aff
Gilles Tremblay

Bibliographic record

VenuePubMed · 2007
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHeme Oxygenase-1 and Carbon Monoxide
Canadian institutionsnot available
Fundersnot available
KeywordsTuberculosisIndustrialisationMedicineUrbanizationContext (archaeology)CoalDiseaseMycobacterium tuberculosisChinaEnvironmental healthEconomic growthPathologyEconomicsGeography
DOInot available

Abstract

fetched live from OpenAlex

Tuberculosis (TB) is generally considered to be linked to industrialisation and urbanisation. Peaking in the 1800s and receding slowly after, the disease declined sharply in the West after World War II. TB has made a comeback in the last 20 years in developing countries such as China and India. Because socio-economic conditions alone cannot explain the connection between industrialisation and TB, factors remain to be determined in the aetiology of the disease. Historical statistics on coal consumption and TB disease in Canada, USA and China are correlated. A hypothesis linking TB and air pollution is developed in the context of industrialisation. A model is proposed whereby triggering of the interleukin-10 (IL-10) cascade by carbon monoxide in lung macrophages promotes the reactivation of Mycobacterium tuberculosis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.032

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.010
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0030.004
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0100.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.208
Teacher spread0.196 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations44
Published2007
Admission routes1
Has abstractyes

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