Bibliographic record
Abstract
A major family of Ca2+-binding proteins is the “EF-hand” superfamily (1), so-called because they all contain “EF-hand” helix-loop-helix Ca2+-binding motifs. These motifs predominantly exist in pairs in these proteins, which is important for high-affinity, cooperative binding of Ca2+ions. Separation of individual helix-loop-helix domains through proteolysis provides an ideal starting point to asses the importance of having these domains in pairs. In addition to proteolytic methods, helix-loop-helix domains can be synthesized chemically through solid-phase peptide synthesis (2). This permits total freedom in choosing mutation sites and the location of the start and end of the polypeptide chains, but can be cost-prohibitive because of the size (approx 35 residues) of the peptides needed. Whatever the route they obtain, isolated EF-hands are interesting models of Ca2+-binding proteins. Often, these isolated motifs, such as thrombic fragements of calmodulin (CaM) (3) and synthetic troponin-C peptides (2,4,5,4,5) dimerize in vitro to form native-like structures.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".