A Case of Cronkhite-Canada Syndrome Involving the Entire Gastrointestinal Tract
Bibliographic record
Abstract
We encountered a case of a 56-year-old woman with Cronkhite-Canada syndrome who presented with chronic diarrhea, alopecia, intermittent abdominal pain, hyperpigmentation, and nail dystrophy (Figure [1]). Her face, palms, and the back of her hands and soles of her feet were deeply pigmented with small dark brown spots. Her family history was noncontributory. Serum total protein was 5.4 g/dl, with 2.4 g/dl of albumin. Endoscopic examination of the stomach showed multiple sessile polyps, varying in size from 2 mm to 10 mm throughout the entire stomach and duodenum (Figure [2]). Small-bowel x-ray and colonoscopic examination revealed multiple polyps from the jejunum to the rectum. Histopathologic examination of these polyps revealed edema of the lamina propria, and mucosal erosion associated with evidence of chronic inflammation. Scintigraphy with technetium-99m-labeled human albumin demonstrated a protein-losing enteropathy. Hyperalimentation (2200kcal/d) was continued for 8 weeks. At 1 week later, the patient's diarrhea showed a decrease in severity, with improvement in appetite and weight gain. However, the diarrhea recurred after 2 weeks. After administration of prednisolone, 30 mg daily, and trimethoprim with sulfamethoxazole (Bactrim), clinical improvement was noted, with cessation of diarrhea, increased serum protein, disappearance of pigmentation, and regrowth of the scalp hair.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".