QOS-57BEHAVIOR IN SURVIVORS OF PEDIATRIC MEDULLOBLASTOMA: THE IMPACT OF COGNITIVE FLEXIBILITY, INTELLIGENCE, AND NEGATIVE AFFECT
Bibliographic record
Abstract
Characterization of medical and neurocognitive outcomes has been a primary focus in survivors of pediatric medulloblastoma. Less studied is the effect of treatment for medulloblastoma on behavioral functioning, and the contribution of cognitive and affective factors. Elevated rates of behavior problems (i.e., withdrawal, poor social functioning) have been documented in survivors of medulloblastoma compared to age-matched peers. We investigated behavioural outcome in survivors compared to controls, and evaluated the mediating impact of intelligence, cognitive flexibility and affect on the associations between treatment and behavior using path analysis. We assessed behavior in twenty-five survivors of medulloblastoma and twenty healthy children using the Child Behavior Checklist. Intelligence, cognitive flexibility and affect were measured with the Wechsler Abbreviated Scale of Intelligence, the Delis-Kaplan Executive Function System and the Early Adolescent Temperament Questionnaire-Revised, respectively. We found that survivors had increased social problems and internalizing behavior compared to controls (p < .01). In our path model, treatment for medulloblastoma predicted subsequent negative affect (β = .38,z = 2.75,p < .01), that in turn was associated with internalizing behavior (β = .48,z = 4.20,p < .0001), which significantly predicted social problems (β = .44,z = 3.17,p < .01). Similarly, treatment for medulloblastoma was associated with subsequent cognitive flexibility deficits (β = -.57,z = -4.58,p < .0001), that in turn predicted internalizing behavior (β = -.34,z = -2.71,p < .01), which significantly predicted social problems (β = .44,z = 3.17,p < .01). Our findings help explain the reported behavior problems in survivors; namely, poor cognitive flexibility and negative affect contribute to reduced social competence and maladaptive internalizing behavior following treatment for medulloblastoma. This increased understanding may help guide and develop intervention programs to promote successful and positive social and emotional functioning in survivors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".