MétaCan
Menu
Back to cohort
Record W2438112359 · doi:10.1007/978-1-59745-406-3_1

The Intranuclear Environment

2008· review· en· W2438112359 on OpenAlexaff
Santiago Schnell, Ronald Hancock

Bibliographic record

VenueMethods in molecular biology · 2008
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsUniversité LavalHotel Dieu Hospital
FundersNational Institute of General Medical Sciences
KeywordsCounterintuitiveNucleusRange (aeronautics)Space (punctuation)MacromoleculeChemical physicsPhysicsNanotechnologyBiophysicsStatistical physicsChemistryBiologyNeuroscienceComputer scienceMaterials scienceQuantum mechanics

Abstract

fetched live from OpenAlex

Many of the chapters in this volume are concerned with processes or structures inside the nucleus, and it is relevant to consider the properties of their environment, or rather of the multiple different and specific environments that must exist in local regions of the highly heterogeneous intranuclear space. Relatively little is known about the fundamental physical properties of these environments, and theoretical treatments of phenomena in such concentrated mixtures of charged macromolecules are complex and as yet poorly developed. Some of the phenomena that occur at the molecular level are unexpected and counterintuitive for biologists, although well known to colloid and polymer scientists; for example, the existence of short-range attractive forces between macromolecules or structures with like charges. As a background for the chapters that follow, we consider here some of the particular features of intranuclear environments, how they may influence processes and structures in the nucleus, and their implications for working with nuclei.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.008
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.003
Open science0.0010.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0080.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.374
Teacher spread0.349 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2008
Admission routes1
Has abstractyes

Explore more

Same venueMethods in molecular biologySame topicGene Regulatory Network AnalysisFrench-language works237,207