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Record W2439157697 · doi:10.4088/jcp.11ac07093

Rediscovering Adverse Anticholinergic Effects

2011· review· en· W2439157697 on OpenAlexaff
Philip Gerretsen, Bruce G. Pollock

Bibliographic record

VenueThe Journal of Clinical Psychiatry · 2011
Typereview
Languageen
FieldMedicine
TopicTreatment of Major Depression
Canadian institutionsCentre for Addiction and Mental Health
Fundersnot available
KeywordsAnticholinergicTricyclicAdverse effectConcomitantAnticholinergic agentsPsychiatryMedicineExtrapyramidal symptomsPsychologyAnesthesiaPharmacologySchizophrenia (object-oriented programming)Internal medicineAntipsychotic

Abstract

fetched live from OpenAlex

Article Abstract Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. A generation ago, psychiatrists were very familiar with anticholinergic adverse effects due to the common use of tricyclic antidepressants and typical antipsychotics with concomitant anticholinergic drugs to manage extrapyramidal symptoms. However, since the introduction of atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs), prescribers generally appear to have become less mindful of the anticholinergic neuropsychiatric effects that can occur in vulnerable patient populations, such as the elderly. In conjunction with this development, the proportion of older patients seen by most psychiatrists has risen.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.015
Threshold uncertainty score0.050

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0150.007

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.133
GPT teacher head0.477
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2011
Admission routes1
Has abstractyes

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