Differential Sclerostin Response To A Plyometric Exercise Session In Boys And Men
Bibliographic record
Abstract
Sclerostin is a protein encoded by the SOST gene; a negative regulator of bone that acts through inhibition of Wnt signaling and bone formation. Circulating sclerostin levels decrease during puberty and increase in adulthood. Another central player in bone turnover is parathyroid hormone (PTH), which stimulates bone resorption. Sclerostin has been shown to decrease following 24 hr mechanical stimulation in mature mice. Its response to exercise in humans and, especially in children, in whom high impact physical exercise benefits bone structure and mineralization, is unclear. PURPOSE: To investigate the acute response of sclerostin to an exercise session consisting of high mechanical loading in boys and men. METHODS: Twelve boys (10.2±1.3 y.o) and 14 young men (22.0±2.8 y.o) underwent a protocol of plyometric jumping exercises (total 144 jumps). Blood samples were collected pre, 5 minutes, 1 hour and 24 hours post-exercise session. Sclerostin and parathyroid hormone (PTH) were measured in the serum using commercial ELISA kits. RESULTS: Boys had significantly (p<0.05) higher resting values of sclerostin compared with men (150±37 vs. 112±34 pg/ml, respectively), but no difference in resting PTH values. Following exercise, sclerostin increased significantly in men but not in boys (at 5 min: 53±37% vs. 14±22%, respectively, p=0.002)). PTH levels were similar in boys and men throughout the 24-hour study period, increasing after 5 min and decreasing subsequently. CONCLUSION: Although the PTH response was similar in boys and men, sclerostin response was markedly different: a session of high impact exercise resulted in immediate increase in sclerostin in men but not in boys. The underlying mechanisms and implication of this differential response on bone formation and resorption need to be examined. Supported by Brock University and NIH Grant P01HD-04872
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".