Running Induces Gut Injury but Does Not Modulate Postprandial Release of Dietary Protein Derived-amino acids
Bibliographic record
Abstract
Resistance exercise has been shown to induce intestinal injury that can impair dietary protein digestion and absorption kinetics during recovery from exercise in young men. Although, endurance exercise can induce pronounced intestinal ischemia and gut injury, the effect of this exercise modality on the subsequent postprandial appearance of dietary protein-derived amino acids has yet to be examined. PURPOSE: We aimed to determine the effects of treadmill running on markers of intestinal injury and the subsequent release of dietary protein- derived leucine in circulation during recovery from exercise in trained athletes. METHODS: In crossover trials, six trained men (27±2 y; BMI= 24±0.9 kg/m2; VO2peak=62±4 ml/kg/min) received a primed continuous infusion of L-[1-13C]leucine and ingested 19 g of intrinsically L-[5,5,5-2H3]leucine labeled egg protein with 60 g carbohydrates at rest and after 1 h of treadmill running at 70%VO2peak. Blood samples were drawn every 0.5-1 h during the infusion protocols to determine amino acid concentrations, leucine enrichments, and intestinal fatty acid binding protein (I-FABP) as an estimate of small intestine injury. RESULTS: I-FABP increased throughout exercise with values peaking immediately after exercise (156% above baseline) but returning to baseline within 30 min of recovery. I-FABP was stable before and after protein ingestion in the resting condition (P>0.05). Postprandial release of dietary protein derived leucine did not differ between the rest and exercise conditions (P=0.33). CONCLUSION: Running induces small intestinal injury but does not affect splanchnic extraction of leucine from dietary protein during recovery from endurance exercise in trained athletes. These data suggest that endurance exercise-induced gut injury does not compromise protein delivery of a mixed meal during post-exercise recovery. Supported by the UIUC Center on Health, Aging, and Disability and the Faculty of Kinesiology and Physical Education Research Grants
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".