Cytokine Responses to Acute Intermittent Aerobic Exercise in Children with Prader-Willi Syndrome and Nonsyndromic Obesity
Bibliographic record
Abstract
Cytokines released in response to exercise, such as interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10), play a role in regulation of metabolism, muscle growth, and general pro-and anti-inflammatory processes. Obesity affects acute cytokine responses to exercise in adults, but the responses in children are less clear. Prader-Willi Syndrome (PWS), the most common form of syndromic childhood obesity, is characterized by hyperphagia, growth hormone deficiency, high fat mass, and low lean mass. PURPOSE: To determine if nonsyndromic obesity and/or PWS affected cytokine responses to acute intermittent aerobic exercise in children. METHODS: Eleven children with PWS (10.9±1.6 y, 45.4±9.5 % body fat), 12 obese (OB) children (9.2±1.2 y, 39.9±6.8 % body fat), and 12 lean (LN) children (9.4±1.2 y, 17.5±4.6 % body fat) participated. Children completed ten two-minute cycle ergometer exercise bouts of moderate intensity, separated by one-minute rest. Blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 15, 30, and 60 minutes into recovery. Samples were analyzed for IL-6, IL-8 and IL-10. RESULTS: In all groups, IL-6 and IL-8 concentrations were greater during recovery compared to PRE. PWS and OB exhibited higher IL-6 area under the curve (AUC) than LN (median [interquartile range], PWS= 67.17[37.50, 78.23], OB= 68.25[43.69, 93.44], LN= 29.25[27.10, 35.44] pgmin/mL; p<0.01 for both). PWS presented higher IL-8 AUC than LN (median [interquartile range], 315.75[249.00, 369.75] vs. 247.13[192.19, 269.06] pgmin/mL; p<0.04). IL-10 did not change with exercise. CONCLUSION: Acute bouts of intermittent aerobic exercise of at least 30 minutes elicited recovery period elevations of systemic IL-6 and IL-8 concentrations, with no changes in IL-10 concentrations; this response was independent of excess body fat. Both obese and PWS children had higher overall concentrations of IL-6 and IL-8 in response to exercise; this suggests that excessive adiposity leads to a greater integrated cytokine response.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".