In vivo Effects of Intraperitoneally Injected ʟ-AsparaginaseSolution and ʟ-Asparaginase Immobilized within SemipermeableNylon Microcapsules with Emphasis on Blood ʟ-Asparaginase,‘Body’ ʟ-Asparaginase, and Plasma ʟ-Asparagine Levels
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
C3H/HEJ mice were given i.p. injections of one of the following: ʟ-asparaginase solution, microencapsulated ʟ-asparaginase, saline or control microcapsules. After injection of ʟ-asparaginase solution, enzyme activity appeared in the blood very rapidly with the highest concentration occurring after 4 h, and was then cleared from the circulation with a half-life of 4.4 h. In marked contrast, when microencapsulated ʟ-asparaginase was injected, no significant ʟ-asparaginase activity appeared in the blood for the entire duration of this study. ‘Body’ ʟ-asparaginase levels declined very rapidly with a half-life of 2 h after injection of ʟ-asparaginase solution, whereas it took 60-72 h for the ‘body' ʟ-asparaginase to decrease to 50% of the original activity after injection of microencapsulated ʟ-asparaginase. The microencapsulated ʟ-asparaginase still retained about 20% of its original activity up to 16 days after injection. Plasma ʟ-asparagine was maintained at zero concentration for 3 days after injection of ʟ-asparaginase solution, compared to 8 days after injection for microencapsulated ʟ-asparaginase. Liver ʟ-asparaginase activity was found to increase after injection of ʟ-asparaginase solution but not after injection of microencapsulated ʟ-asparaginase. The response of the host to i.p. injection of nylon microcapsules is described. Preliminary experiments indicate that the half-life for clearance of the free enzyme from the circulation of 6C3HED lymphosarcoma-bearing mice was 13.2 h as compared to 4.4 h for normal mice, and that microencapsulated ʟ-asparaginase was capable of causing regression of the tumor in the advanced, well-established stage.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it