Cu/Pd-Catalyzed Synthesis of Fully Decorated Polycyclic Triazoles: Introducing C–H Functionalization to Multicomponent Multicatalytic Reactions ((MC)<sup>2</sup>R)
Bibliographic record
Abstract
A robust method for the dual-metal-catalyzed combination of organic azides, terminal alkynes, and internal alkynes is reported. The reaction is initiated with a chemoselective copper-catalyzed azide alkyne cycloaddition (CuAAC) followed by a palladium-catalyzed incorporation of an internal alkyne. The simple one-pot procedure introduces C–H functionalization to the growing field of multicomponent multicatalytic reactions ((MC) 2 R). With inexpensive CuI and the Herrmann–Beller palladacycle as catalysts, four bonds and two heterocyclic rings are created with HI as the sole byproduct. The broad scope with respect to all components showcases this versatile transformation, leading to a new class of fully substituted polycyclic triazoles. 1 H NMR and deuterium-labeling studies provide insight into the rate differences of the copper and palladium steps.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".