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2015· article· en· W2476374547 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueCurrent Genomics · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRNA modifications and cancer
Canadian institutionsnot available
Fundersnot available
KeywordsEditorial boardComputer scienceBusinessLibrary science

Abstract

fetched live from OpenAlex

I was born in Leningrad, Soviet Union in 1951, and have received my B.Sc. in Biology/Biophysics (1971) and M.Sc. in Biochemistry (1973) from the Faculty of Biological Sciences at the Leningrad State University. After receiving my Ph.D. Degree in Molecular Biology and Cancer Biology (1979) from the Petrov Cancer Research Institute, I was continuing my research as a research scientist there. In 1983, I was accepted as a senior research scientist into a newly organized Department of Genetic Engineering at the Institute of Cytology, Leningrad, USSR. In 1990, I immigrated to Israel and started working as an Instructor at the Weizmann Institute of Science, Rehovot, Israel, where I studied the interferon type I receptor signaling at the Department of Molecular Virology under the supervision of Prof. Michel Revel, the leader in cytokine signaling. During my tenure at Weizmann, I was awarded a British Council Award to study in ICI/Zeneca Pharmaceuticals (Alderley Park, UK) allowing me to extend my expertise in yeast genetic engineering. In 1994, I was invited to join the Johns Hopkins University School of (Baltimore, Maryland, USA), as an Assistant Professor of Pathology, where I have developed a strong long-lasting interest in protein-protein interaction studies in cardiovascular and cancer diseases. This approach helped me to discover a novel midkine-dependent signaling pathway, the regulatory proteins affecting the NOS2 activity/dimerization/ degradation, and finally, I have focused on the p63 transcriptional factor implicated in head and neck cancer and ectodermal dysplasia. In 2000, I was promoted to the rank of an Associate Professor of Dermatology/Otolaryngology-Head and Neck Surgery/Oncology and then later to the rank of Professor. Since then my laboratory was able to discover a molecular mechanism underlying ectodermal dysplasia via p63-dependent regulation of RNA splicing for fibroblast growth factor receptor 2, which functions as a key regulator of the epithelial-mesenchymal transition. Since 2004, I have become an Associate Director of Head and Neck Cancer Research Division at the Johns Hopkins. In the same year I have become a member of the Graduate Training Program in Cellular and Molecular at JHMI. In 2008, I have joined the Wilmer Glia Research Laboratory Collaborative Network and Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins Neurofibromatosis Research Center. In 2013, I have also become an Adjunct Professor at the George Washington University (GWIN, SEAS), Washington-DC, USA. To the present date, my collaborative efforts with Drs. David Sidransky and Barry Trink (the researchers who first discovered p53 homologue p63) led to more than 40 international publications, reviews, book chapters and patents on p63 function alone. My name was included in the books 2000 Outstanding Scientists of the 21st Century, Great Minds of the 21st Century and is Who in Medicine (since 2005). I am a Member of the New York Academy of Sciences, International Society on Interferon and Cytokine Research, American Society for Cell Biology, American Association for Cancer Research, International Society for Cell Biology, Society for Investigative Dermatology, American Society for Biochemistry and Molecular Biology, International Society for Stem Cell Research. I am a Member of the Executive Advlsory Board, Biotech/Medical Board, and Sustainability Board of Lifeboat Foundation, and Task Force: Getting to know Cancer. Halifax Project. In 2014-2015, I was awarded a Distinguished Visiting Professorship by an Ecuador Prometeo Foundation and served in the Department of Human Genetics at the La Universidad Tecnica Particular de Loja (UTPL), Loja, Ecuador.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.071
Threshold uncertainty score0.370

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.318
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it