Glutamate Receptors and Synaptic Physiology in Developing Neural Circuits
Bibliographic record
Abstract
The major excitatory neurotransmitter in the CNS is glutamate. It binds to and activates fast, ligand-gated receptors such as AMPA and NMDA ionotropic receptors. AMPA receptors are composed of 4 subunits (GluA1–4) with varying stoichiometries. The subunit composition of the AMPA receptors imparts different properties to the receptor channels such as time course, conductance states, rectification, and calcium permeability. In some preparations AMPA receptors appear to switch subunits during development, but the reasons for this switch and the mechanisms that underlie it remain largely unknown. To address these issues, we examine synaptic plasticity phenomena related to AMPA receptor subunit composition in embryonic zebrafish. Specifically, we record AMPA receptor activity associated with Mauthner neurons. This is one of the rare vertebrate preparations in which one can study developmental synaptic plasticity in the same cell from organism to organism.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".