Postsynaptic Excitatory Transmission
Bibliographic record
Abstract
The vast majority of excitatory synapses in the mammalian central nervous system employ glutamate as their transmitter. Glutamatergic transmission therefore generates most excitatory synaptic potentials (epsps); and, regulation of postsynaptic receptors for glutamate is a pivotal means of altering excitatory synaptic transmission to produce various forms of synaptic plasticity. Interactions between glutamate receptors in the same synapse, or in the extrasynaptic region of the neuron membrane are likely to alter their function and their surface expression in the plasma membrane. Glutamate receptors are also the target of modifications by the postsynaptic receptors of “long” transmitter systems (e.g., cholinergic and dopaminergic systems). We have shown that long-distance cross-talk between receptors for “long” transmitters and glutamate receptors occurs through the sharing of overlapping signal transduction pathways and may also make use of the signal relay mechanism of growth factor receptor “transactivation”.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".