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Record W2481575045 · doi:10.1017/cbo9781107447615.023

Synaptic plasticity and learning

2014· book-chapter· en· W2481575045 on OpenAlexaff
Wulfram Gerstner, Richard Naud, Liam Paninski

Bibliographic record

VenueCambridge University Press eBooks · 2014
Typebook-chapter
Languageen
FieldNeuroscience
TopicNeural dynamics and brain function
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsSynaptic augmentationLong-term potentiationNeuroscienceSynaptic plasticityNeural facilitationMetaplasticitySynaptic fatigueNonsynaptic plasticityPostsynaptic potentialPost-tetanic potentiationSynapseSynaptic scalingHomosynaptic plasticityFacilitationExcitatory postsynaptic potentialPsychologyBiologyInhibitory postsynaptic potentialReceptor

Abstract

fetched live from OpenAlex

In the network models discussed in Parts III and IV, each synapse has so far been characterized by a single constant parameter w ij , called the synaptic weight, synaptic strength, or synaptic efficacy. If w ij is constant, the amplitude of the response of a postsynaptic neuron i to the arrival of action potentials from a presynaptic neuron j should always be the same. Electrophysiological experiments, however, show that the response amplitude is not fixed but can change over time. In experimental neuroscience, changes of the synaptic strength are called synaptic plasticity. Appropriate stimulation paradigms can induce changes of the postsynaptic response that last for hours or days. If the stimulation paradigm leads to a persistent increase of the synaptic efficacy, the effect is called long-term potentiation of synapses, or LTP for short. If the result is a decrease of the synaptic efficacy, it is called long-term depression (LTD). These persistent changes are thought to be the neuronal correlate of learning and memory. LTP and LTD are different from short-term synaptic plasticity such as synaptic facilitation or depression that we have encountered in Section 3.1. Facilitated or depressed synapses decay back to their normal strength within less than a few seconds, whereas, after an LTP or LTD protocol, synapses keep their new values for hours. The long-term storage of the new values is thought to be the basis of long-lasting memories.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.011
Threshold uncertainty score0.036

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.002
Scholarly communication0.0020.003
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0110.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.186
Teacher spread0.164 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations5
Published2014
Admission routes1
Has abstractyes

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