Bibliographic record
Abstract
Several conditions of pathological pain involve plastic changes in GABA/glycine-mediated inhibition in the CNS which can (i) alter the gain of the response to nociceptive input (hyperalgesia), but also(ii) allow cross talk between non-nociceptive and nociceptive pathways as a substrate for aberrant pain perception to normally innocuous input (allodynia). While plasticity of the GABA/glycine system had been traditionally overlooked and poorly studied, especially in the context of the pain system, recent findings highlight a richness of mechanisms by which inhibition is modulated that open several avenues for innovative therapeutic treatment for the prevention, as well as the reversal of pathological pain. These findings include (i) evidence of highly plastic GABA/glycine co-synapses, (ii) modulation of specific receptor subclasses by endogenous agents traditionally thought to act mainly in the periphery, but which also act centrally (e.g., neurosteroids and prostaglandins) and (iii) active regulation of anion homeostasis as a means to modulate both the strength and the sign of GABA/glycine action (i.e., excitatory vs.inhibitory).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".